This enhanced nutrient availability supports higher protein synthesis rates, leading to increased yields of the desired vaccine antigens.Įnabling Scale-Up and Process OptimizationĪs mRNA vaccine candidates progress through preclinical and clinical development, the need for large-scale production becomes paramount. The shaking motion helps to overcome mass transfer limitations, ensuring uniform distribution of nutrients and oxygen throughout the cell culture. Incubator shakers aid in optimizing protein expression by providing a controlled environment that facilitates the translation of mRNA into proteins. Once mRNA molecules are successfully transfected into cells, the next step is to ensure efficient protein expression. This improved transfection efficiency translates into higher yields of mRNA-transfected cells, which are essential for subsequent stages of vaccine development and testing. The shaking motion creates gentle agitation, helping to improve the contact between mRNA molecules and cell membranes, thereby facilitating higher uptake rates. Incubator shakers play a crucial role in improving transfection efficiency by enhancing the delivery of mRNA molecules into cells. Transfection, the process of introducing mRNA molecules into cells, is a vital step in mRNA vaccine development. This level of control not only enhances the yield and purity of mRNA but also reduces the likelihood of experimental variability, increasing the reliability of results. They maintain precise temperature, humidity and agitation levels, allowing cells to thrive and efficiently carry out the protein synthesis process. Incubation shakers are specialized instruments designed to create optimal growth conditions and controlled environments for cultures ensuring that mRNA molecules are efficiently translated into proteins. The research and development of mRNA technologies rely heavily on the use of advanced laboratory equipment, with incubation shakers playing a crucial role as the “universal workhorse” of mRNA-based therapy development. To facilitate the development and production of mRNA vaccines, it is essential to have advanced laboratory equipment that meets the stringent requirements of this specialized field.Īddressing the Unique Challenges of mRNA Vaccine Development After the battle against the pandemic, the field of cancer therapies is now in the focus of research, where mRNA is a very promising approach. This method has proven immensely successful in the development of COVID-19 vaccines, enabling rapid response and deployment. Once inside our cells, this mRNA is translated into the viral protein, triggering an immune response without causing the actual infection. However, mRNA vaccines take a different approach by delivering a small piece of synthetic mRNA that encodes a viral protein. Traditional vaccines often involve introducing weakened or inactivated pathogens to stimulate an immune response. Temperature control, the ability to shake and incorporate injectors, and BMG’s capable control and analysis software, compatible with stringent GLP and GMP requirements, give the PHERAstar FSX a versatility that is hard to match.īoth units are also backed by the extensive experience of Biogen Científica, distributor of both manufacturers since the 90’s, and responsible for the installation and maintenance of several hundred of them distributed throughout laboratories in the Iberian Peninsula.At the heart of mRNA technology lies the ability to develop vaccines and therapeutics that work in harmony with our own immune systems. Thanks to its unique optical module system, dual simultaneous emission, UV/Vis spectrometer and dedicated AlphaScreen® and TRF lasers, the PHERAstar FSX has unmatched detection limits, so it can perform any assay with extraordinary ease and speed, even using 3456-well microplates. It combines extraordinary sensitivity with ultra-fast read times. The PHERAstar FSX is the most powerful multi-mode reader for HTS. All with the possibility of remote control through the most complete software for Bioprocesses, the EVE. It has multiple possibilities to adapt to the needs of each laboratory, such as 3, 25 or 50 mm orbit, precise temperature and speed control, CO2 regulation, humidification and illumination. In addition, it is possible to stack up to three units, the third tray being at a very accessible height (130 cm). The Multitron IV is the highest capacity unit in its class (up to 6 x 5 L flasks) despite its compact external dimensions and weight. The Multitron IV from the Swiss manufacturer Infors HT is the ideal solution for mammalian cell culture. Biotechforum / Health&Research forum Conferences.Photos and videos of Farmaforum editions.
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